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ABSTRACT Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on… Click to show full abstract
ABSTRACT Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progenitors to control infection and to eradicate tumors.
Keywords:
myeloid progenitors;
expansion differentiation;
stem cells;
hematopoietic stem
Journal Title: OncoImmunology
Year Published: 2018
Link to full text (if available)
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Journal Title: OncoImmunology
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!