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The intestinal microbiota determines the clinical efficacy of immune checkpoint blockers targeting PD-1/PD-L1

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ABSTRACT Cancer immunotherapists have been searching for biomarkers predicting patient responses to PD-1/PD-L1 blockade in neoplastic cells as well as in the immune system. Now, accumulating evidence indicates that the… Click to show full abstract

ABSTRACT Cancer immunotherapists have been searching for biomarkers predicting patient responses to PD-1/PD-L1 blockade in neoplastic cells as well as in the immune system. Now, accumulating evidence indicates that the composition of the intestinal microflora has a major impact on patient prognosis. Here, we enumerate the bacterial species that are associated with favorable outcome of immunotherapy.

Keywords: immune checkpoint; microbiota determines; clinical efficacy; intestinal microbiota; determines clinical; efficacy immune

Journal Title: OncoImmunology
Year Published: 2018

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