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ABSTRACT Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an… Click to show full abstract
ABSTRACT Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in dendritic cells, causing the subversion of cancer therapy-elicited antineoplastic immune responses and subsequent therapeutic failure.
Keywords:
abolish efficacy;
exogenous glucocorticoids;
glucocorticoids abolish;
cancer;
endogenous exogenous;
efficacy immune
Journal Title: Oncoimmunology
Year Published: 2020
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Journal Title: Oncoimmunology
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!