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ABSTRACT Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and… Click to show full abstract
ABSTRACT Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.
Keywords:
faceted tools;
extracellular vesicles;
multi faceted;
tools leukemia;
vesicles multi;
small extracellular
Journal Title: Oncoimmunology
Year Published: 2022
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Journal Title: Oncoimmunology
Year Published: 2022
Link to full text (if available)
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recommendations!