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Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child

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Abstract A child with pre-B acute lymphoblastic leukaemia (ALL) developed fatal encephalitis associated with human coronavirus OC43 (HCoV-OC43). During chemotherapy the child had a persistent HCoV-OC43 respiratory infection and later… Click to show full abstract

Abstract A child with pre-B acute lymphoblastic leukaemia (ALL) developed fatal encephalitis associated with human coronavirus OC43 (HCoV-OC43). During chemotherapy the child had a persistent HCoV-OC43 respiratory infection and later developed progressive encephalitis. Cerebrospinal fluid was negative for pathogens including HCoV-OC43, but a brain biopsy was HCoV-OC43-positive by metagenomic next-generation sequencing.

Keywords: hcov oc43; oc43; coronavirus oc43; encephalitis associated; encephalitis; fatal encephalitis

Journal Title: Infectious Diseases
Year Published: 2020

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