LAUSR

ABSTRACT The wound-healing process is important in treating acute and chronic injuries. It is a multi-faceted process, often with obstacles that hinder successful healing. These obstacles include infections, inadequate circulation, and diabetes. Metal-organic-frameworks (MOFs), a class of porous-coordinated-polymer materials, have exceptional loading capacity and antimicrobial properties. Their distinct structure enables them to absorb and gradually release drugs or therapeutic agents, making them an outstanding choice for wound dressings. Metal-phenolic-networks (MPNs), with metal ions and phenolic compounds, form a stable, flexible framework. When MPNs are applied to wounds, they promote tissue regeneration and accelerate healing. Covalent-organic-frameworks (COFs) are materials made of interconnected organic molecules that create functional systems through covalent bonds, resulting in a porous-crystalline structure. These elements have been studied for potential applications such as drug delivery and catalytic reactions. According to recent research, it is unlikely that COFs are beneficial for wound-healing. MOFs and MPNs enhance wound-healing by stimulating cell growth and tissue regeneration. The originality of this review lies in the comparative analysis of MOFs, MPNs, and COFs to identify mechanisms, advantages, and limitations, with the aim of improving the design of advanced wound dressing platforms. This organization includes working principles, therapeutic applications, challenges, future developments, and concluding remarks. GRAPHICAL ABSTRACT