In this study, the composite of prussian blue-carboxylated MWCNTs/ZIF-67 (PB-MWCNTs-COOH/ZIF-67) was synthesized and used as modified electrode material to fabricate an electrochemical sensor for the determination of paracetamol (PAR). In… Click to show full abstract
In this study, the composite of prussian blue-carboxylated MWCNTs/ZIF-67 (PB-MWCNTs-COOH/ZIF-67) was synthesized and used as modified electrode material to fabricate an electrochemical sensor for the determination of paracetamol (PAR). In this sensor system, negatively charged MWCNTs-COOH as support for the immobilization of positively charged PB can effectively avoid the agglomeration of PB and enhance the stability, conductivity and catalytic activity of the composite. ZIF-67 particles coating outside PB-MWCNTs-COOH promotes the concentration of PAR. Benefiting from the synergistic effect, the PB-MWCNTs-COOH/ZIF-67 based sensor exhibits significantly improved electrochemical sensing behavior toward the oxidation of PAR. Under the optimum conditions, the PAR sensor presents wide linear ranges of 0.01-70 μM with a low limit of detection (LOD) of 3.3 nM (S/N= 3). The method also possesses long-term stability, good reproducibility and selectivity, and was employed to the determination of PAR contents in PAR tablets sample.
               
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