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Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'.

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In this reply we present additional description of our linear model for LET optimization in response to the comments by Dr Gorissen. We clarify that this model cannot guarantee global… Click to show full abstract

In this reply we present additional description of our linear model for LET optimization in response to the comments by Dr Gorissen. We clarify that this model cannot guarantee global optimal solutions to the sum-of-fractions problem. Based on our data, it could be used to optimize LET efficiently while dose constraints are maintained.

Keywords: energy transfer; incorporated intensity; comment linear; reply comment; transfer incorporated; linear energy

Journal Title: Physics in medicine and biology
Year Published: 2019

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