LAUSR

OBJECTIVE This study employs a recently developed experimental technique for comparison of the flow characteristics and the effectiveness of gas washout between pressure control ventilation (PCV) and high-frequency percussive ventilation (HFPV) in high-compliance and low-compliance ex vivo porcine respiratory tracts. APPROACH The ex vivo porcine lungs are filled with nitrogen prior to ventilating with atmospheric gas using either PCV or HFPV to investigate the flow characteristics and gas washout characteristics. The study considered freshly removed lungs from porcine carcasses that were humanely harvested for human consumption. Subsequently, the porcine lungs were exposed externally to formalin to simulate low-compliance conditions. The first order models of respiratory mechanics were employed to predict the lung compliance and resistance in normal and formalin exposed lungs. HFPV was operated in two different modes based upon the set pressures, namely HFPV-Low and HFPV-High. The peak pressures of HFPV and PCV were matched in HFPV-Low and the peak pressures are increased to about 20-30% in the HFPV-High mode. MAIN RESULTS Both HFPV-Low and HFPV-High mode deliver smaller tidal volume (V T) as compared to PCV in high and compliance states (about 70% and 40% for healthy and formalin treated lungs, repsectively). Although the tidal volume delivered by HFPV-High and HFPV-Low are comparable, they reveal a substantial difference in washout time as well as total ventilation volumes. In a high compliant lung (healthy lung), HFPV-High washes out the nitrogen within the lung more rapidly, whereas HFPV-Low washes out the inert gas more slowly as compared to PCV. In a low-compliance lung, HFPV-Low delivers similar washout rates as PCV at a much smaller V T and lower mean airway pressure. SIGNIFICANCE The ex vivo study supports the hypothesis that in low compliant lungs HFPV provides effective washout with a protective ventilation.