LAUSR

The paper presents the results of studying the interactions of oxidized nanodiamonds with lysozyme in water. It was found that lysozyme is actively adsorbed on the surface of nanodiamonds in two layers. For the first time, using the CARS method, it was found that the conformation of lysozyme molecules in the first adsorption layer changes, and the conformation of molecules adsorbed in the second layer almost coincides with the conformation of free lysozyme molecules. The obtained results and the analysis of the literature data concerning the activity of lysozyme allowed us to conclude that lysozyme in the first adsorption layer mainly loses its enzymatic activity, and in the second—retains it.