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OBJECTIVE To analyze the patterns and differences of Chinese herbs in the treatment of coronary heart disease (CHD) in different time periods and different regions in recent 20 years. DESIGN The literature of controlled clinical trials that focuses on Chinese herbs treating CHD published in China National Knowledge Internet and Wanfang database from January 1, 1996 to December 31, 2015 were screened to analyze the patterns of herb utilization using SPSS 21.0. RESULTS A total of 1250 articles were enrolled in total covering 29 regions. There were 242 kinds of single herbs, 18 categories, mentioned a total of 11,594 times. In Northeast China, North China, South China, Central China, and Southwest China the most frequently used herb was Radix Salviae Miltiorrhizae, but in East China and Northwest China, the most frequently used herb was Rhizoma Chuanxiong. The most frequently used herb category in North China, Central China, Southwest China, and Northwest China was herbs to invigorate blood, but in Northeast China, East China, and South China the most frequently used herb category was herbs to tonify. CONCLUSION Single herbs and herb categories to treat CHD in Traditional Chinese Medicine differed from time to time and from region to region.