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Short Communication: Lack of Effect of Maraviroc Intensification on Blood and Gut Reservoir.

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We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term antiretroviral therapy was not associated with improvements in HIV-related morbidity, HIV reservoir, microbial… Click to show full abstract

We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term antiretroviral therapy was not associated with improvements in HIV-related morbidity, HIV reservoir, microbial translocation, immune activation, or immune exhaustion in either gut or peripheral blood. The measurement of reservoir in both gut and blood longitudinally contributes to a paucity of data in the area.

Keywords: maraviroc; gut; reservoir; blood; short communication; intensification

Journal Title: AIDS research and human retroviruses
Year Published: 2017

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