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Abstract This study aimed to explore the contribution of high-mannose glycans in the masking of conserved V3 crown (GPG) and V2i epitopes on the hypervariable loops of most exposed distal… Click to show full abstract
Abstract This study aimed to explore the contribution of high-mannose glycans in the masking of conserved V3 crown (GPG) and V2i epitopes on the hypervariable loops of most exposed distal surface of HIV-1 Env. Using lectins specific to Manα1-2Man residue containing Man6-9GlcNAc2 glycans extensively decorating HIV-1 Env, we found that Manα1-2Man-binding lectins enhance the exposure of these partially and transiently exposed epitopes and consequentially increase the neutralization strength of antibodies against these epitopes.
Keywords:
hypervariable loops;
2man binding;
hiv;
epitopes hypervariable;
man 2man
Journal Title: AIDS Research and Human Retroviruses
Year Published: 2017
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Journal Title: AIDS Research and Human Retroviruses
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!