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High rate of HIV-1 drug resistance in ART-failure patients in Liaoning Province, China.

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BACKGROUND This study aimed to monitor the prevalence of HIV-1 drug resistance and risk factors associated with drug resistance in ART-failure individuals in Liaoning Province, China. PATIENTS AND METHODS Plasma… Click to show full abstract

BACKGROUND This study aimed to monitor the prevalence of HIV-1 drug resistance and risk factors associated with drug resistance in ART-failure individuals in Liaoning Province, China. PATIENTS AND METHODS Plasma samples were collected from HIV-1-positive individuals who experienced ART failure in Liaoning Province between April 2018 and September 2019.Genotype resistance test was performed using an in-house assay on these collected samples. Factors associated with drug resistance were identified by logistic regression analysis. RESULTS We collected a total of 468 ART-failure individuals, of which 256 were successfully included in the final study. Of these, the most predominant genotype was CRF01_AE, accounting for 77.73%. The resistance rate to any of the three classes of antiretroviral drugs (NNRTIs, NRTIs, and PIs) was 64.84%. Among 256 ART-failure patients, 62.89% showed drug resistance to NNRTIs, 50.39% to NRTIs, and 3.13% to PIs. G190S (31.25%) and Y181C (25.78%) mutations were the most common NNRTIs resistance mutations. K65R (29.69%), M184V (28.52%) were the most common NRTIs resistance mutations. Factors associated with drug resistance included current ART regimen and viral load. CONCLUSION The high drug resistance rate among ART-failure individuals in Liaoning Province needs more attention. Corresponding strategies for the risk factors associated with HIV drug resistance can better control and prevent the prevalence of resistance.

Keywords: liaoning province; art failure; resistance; drug resistance

Journal Title: AIDS research and human retroviruses
Year Published: 2022

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