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Identification of a new HIV-1 CRF68_01B/CRF01_AE recombinant form among men who have sex with men in Hebei province, China.

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In recent years, homosexual contact has been the most frequent route of Human immunodeficiency virus type one (HIV-1) transmission in Hebei, China. The number of circulating recombinant forms (CRFs) and… Click to show full abstract

In recent years, homosexual contact has been the most frequent route of Human immunodeficiency virus type one (HIV-1) transmission in Hebei, China. The number of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) found in this key population was more and more. In this study, we identified a novel HIV-1 second-generation recombinant form originated from CRF68_01B and CRF01_AE among men who have sex with men (MSM) via the phylogenetic and recombinant breakpoints analyses based on the near full-length genome (NFLG). Both CRF68_01B and CRF01_AE were circulating in the Hebei province of China, and this MSM was diagnosed as the recent HIV-1 infection in fact. The result reminds that we should constantly monitor HIV-1 diversity in Hebei and take further effective to control the recombination of not only HIV-1 major strains but also minor strains.

Keywords: hiv; recombinant form; 01b crf01; china; crf68 01b

Journal Title: AIDS research and human retroviruses
Year Published: 2022

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