LAUSR

Neuroimaging studies of Intellectual Disability (ID) have been published over the last three decades, but the findings are often inconsistent and therefore the neural correlates of ID remain elusive. The aim of this paper is to study the different publications in task-fMRI and different ID populations in order to make a qualitative and quantitative analysis on this field. After duplicates were removed, only 10 studies matching our inclusion criteria were included and a quality assessment of the included studies was conducted. Qualitative results of the different papers were analyzed, separated by type of task and type of ID. Seed-based d Mapping (SDM) software was used. In the case of metanalysis results, right temporal gyrus was more activated in control subjects than in ID. This area is involved in several cognitive domains including language and semantic memory processing and can be highly influenced by the type of task used in every study. Heterogeneity was not detected. A jackknife sensitivity analysis was also conducted in order to proof the analysis reliability, and both results were confirmed. It is necessary that more task-fMRI studies on ID are published, in order to add larger samples to address the pathophysiological questions more directly.