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Prostaglandin E2 Production by Brain Endothelial Cells and the Generation of Fever

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We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in… Click to show full abstract

We recently demonstrated that prostaglandin production in brain endothelial cells is both necessary and sufficient for the generation of fever during systemic immune challenge. I here discuss this finding in light of the previous literature and point to some unresolved issues.

Keywords: generation fever; endothelial cells; prostaglandin production; production brain; brain endothelial

Journal Title: DNA and Cell Biology
Year Published: 2023

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