LAUSR

Ultraviolet B radiation may influence the occurrence or even worsen cutaneous disorders from inflammatory to neoplastic ones. Dietary restriction (DR) is a well known regimen which can retard aging associated pathologies, and is shown by us and others can significantly inhibit inflammation under various conditions including both un-disturbed and stressful settings. It is unknown whether DR could act as a non-pharmacological factor to protect skin against UVB-induced damage. Here, we performed 30% DR to mice 1 week before UVB irradiation (798.6mj/cm2). Remarkably, continuous DR significantly ameliorated UVB induced skin damage and histological changes, associated with a great reduction in the inflammatory responses in the skin. Intriguingly, re-fed (RF) DR mice with ad libitum diet (AL) even 24 hours post irradiation re-inflamed the inflammatory responses and induced significantly strong damage to the skin. Together, the current study provides the first experimental evidence that DR greatly protects mouse skin from high dose of UVB irradiation, which if translatable could have great implications in human beings.