LAUSR

OBJECTIVE To conduct a systematic literature review to study the effects of fish based biomaterials on wound healing in both in vivo and in vitro animal models. APPROACH The present review covers the study reported in different papers between 2016 to August 2022 concentrating mainly on the cytotoxicity evaluation of different fish based biomaterials on inflammation, re-epithelization and wound healing. SIGNIFICANCE The current review shows considerable amount of research work carried out onwith fish based biomaterials and collagen for treating burn wounds. Surprisingly there isare only a few no commercial products developed so far in this particular regard for surgical purpose medical purpose and therefore, there is an urgent way out and need for developing a medical support product product from fish based biomaterials in order to treat and cure wounds. RECENT ADVANCES 3D skin bio printing technique is a large scale solution for severe burn wounds that requires collagen as a raw material for printing, wherein fish collagen can be used in place of bovine and porcine, as it is biocompatible, promotes cell proliferation, adhesion, migration and degrades enzymatically. In the recent times, there are a few fish based surgical products that have been formulated by Kerecis in United states. CRITICAL ISSUES The different fish based biomaterial products are all mere supplements taken in orally as food or supplements till date and there is no proper proven medications drug which has been formulated so far in the field of wound healing and inflammation based on fish biomaterials except the surgical products that can be finger counted. FUTURE DIRECTIONS Fish based biomaterials are known for the medicinal properties that are used throughout the worldwide and there should be further investigations carried out in order to understand the actual physiochemical properties of its derivatives for the discovery of novel products and drugs.