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Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics

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Temporal and spatial regulation of mitotic motor proteins is required for proper spindle assembly and function. A single microtubule-associated protein, TPX2, regulates both kinesin-5 and kinesin-12 family members to support… Click to show full abstract

Temporal and spatial regulation of mitotic motor proteins is required for proper spindle assembly and function. A single microtubule-associated protein, TPX2, regulates both kinesin-5 and kinesin-12 family members to support bipolar spindle formation and maintenance.

Keywords: microtubule; regulation kif15; tpx2; kif15 localization; localization motility; regulation

Journal Title: Molecular Biology of the Cell
Year Published: 2017

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