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Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space

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Osm1 transfers electrons from fumarate to succinate and functions with Mia40 and Erv1 in the redox-regulated import pathway for proteins that form disulfide bonds in the mitochondrial intermembrane space. Expression… Click to show full abstract

Osm1 transfers electrons from fumarate to succinate and functions with Mia40 and Erv1 in the redox-regulated import pathway for proteins that form disulfide bonds in the mitochondrial intermembrane space. Expression of Osm1 and cytochrome c is reciprocally regulated, indicating that the cell has strategies to coordinate expression of terminal electron acceptors.

Keywords: intermembrane space; import pathway; mitochondrial intermembrane; redox regulated; regulated import

Journal Title: Molecular Biology of the Cell
Year Published: 2017

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