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Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

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Chemotaxis is the mechanism by which cells move in the direction of chemical gradients. The central circuit connecting basal movement and gradient sensing is unknown. Ras activation and F-actin form… Click to show full abstract

Chemotaxis is the mechanism by which cells move in the direction of chemical gradients. The central circuit connecting basal movement and gradient sensing is unknown. Ras activation and F-actin form one coupled excitable system, which is the beating heart of cell movement in both the absence and presence of external cues.

Keywords: cell movement; movement; coupled excitable; excitable ras; activation; cell

Journal Title: Molecular Biology of the Cell
Year Published: 2017

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