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PKC-mediated phosphorylation of nuclear lamins at a single serine residue regulates interphase nuclear size in Xenopus and mammalian cells

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A novel PKC phosphorylation site in lamin B3 influences both nuclear lamina dynamics and nuclear size in Xenopus laevis embryos and extracts. PKC activity also modulates nuclear size in mammalian… Click to show full abstract

A novel PKC phosphorylation site in lamin B3 influences both nuclear lamina dynamics and nuclear size in Xenopus laevis embryos and extracts. PKC activity also modulates nuclear size in mammalian cell culture, and a conserved phosphorylation site in human lamin A affects the association of lamin A with the nuclear envelope and nuclear size.

Keywords: nuclear size; size xenopus; size; pkc mediated; phosphorylation

Journal Title: Molecular Biology of the Cell
Year Published: 2017

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