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For a prototypical GPCR, the human vasopressin receptor type 2 (V2R), βarr1 can form a stable complex associated via only the phosphorylated carboxyl terminus of the receptor. Such a partially… Click to show full abstract
For a prototypical GPCR, the human vasopressin receptor type 2 (V2R), βarr1 can form a stable complex associated via only the phosphorylated carboxyl terminus of the receptor. Such a partially engaged complex is functionally competent with respect to supporting receptor internalization and ERK MAPK activation.
Keywords:
arrestin dispensable;
engagement arrestin;
activation;
receptor;
core engagement;
vasopressin receptor
Journal Title: Molecular Biology of the Cell
Year Published: 2017
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Journal Title: Molecular Biology of the Cell
Year Published: 2017
Link to full text (if available)
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recommendations!