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HPV-transforming protein E6 weakens both SAC activity and sister chromatid cohesion. These processes largely function normally and result in chromosome segregation errors only when mitosis is delayed by the presence… Click to show full abstract
HPV-transforming protein E6 weakens both SAC activity and sister chromatid cohesion. These processes largely function normally and result in chromosome segregation errors only when mitosis is delayed by the presence of one to four unaligned, pole-associated chromosomes. This mechanism of aneuploidy is not observed in response to oncogenic signaling.
Keywords:
chromatid cohesion;
sister chromatid;
hpv
Journal Title: Molecular Biology of the Cell
Year Published: 2017
Link to full text (if available)
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Journal Title: Molecular Biology of the Cell
Year Published: 2017
Link to full text (if available)
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recommendations!