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The ESCRT-I protein TSG101 can mitigate endoplasmic reticulum stress–mediated apoptosis involving caspase 4/12 caused by MGRN1 depletion, probably contributing to neurodegeneration. TSG101 associates with ALIX to prevent predisposition to apoptosis,… Click to show full abstract
The ESCRT-I protein TSG101 can mitigate endoplasmic reticulum stress–mediated apoptosis involving caspase 4/12 caused by MGRN1 depletion, probably contributing to neurodegeneration. TSG101 associates with ALIX to prevent predisposition to apoptosis, whereas ALIX–ALG-2 interaction favors a cell death phenotype.
Keywords:
101 regulates;
apoptosis;
gene 101;
tumor susceptibility;
predisposition apoptosis;
susceptibility gene
Journal Title: Molecular Biology of the Cell
Year Published: 2017
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Journal Title: Molecular Biology of the Cell
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!