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Transcellular tunnels in endothelial cells can be formed by leukocytes and pathogens as a way of crossing the endothelial barrier. Using force microscopy and fluorescence microscopy, we find that the… Click to show full abstract
Transcellular tunnels in endothelial cells can be formed by leukocytes and pathogens as a way of crossing the endothelial barrier. Using force microscopy and fluorescence microscopy, we find that the actin cytoskeleton provides the primary mechanical barrier to transcellular tunnel formation, which can be overcome by force or by toxins.
Keywords:
microscopy;
force;
endothelial cells;
transcellular tunnel;
tunnel formation
Journal Title: Molecular Biology of the Cell
Year Published: 2017
Link to full text (if available)
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Journal Title: Molecular Biology of the Cell
Year Published: 2017
Link to full text (if available)
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recommendations!