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Effects of substrate stiffness and actomyosin contractility on coupling between force transmission and vinculin–paxillin recruitment at single focal adhesions

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The relationship between force and focal adhesion (FA) dynamics is unclear. Substrate stiffness and contractility regulate the relationship between force and vinculin, but not paxillin, turnover at FAs. Substrate stiffness… Click to show full abstract

The relationship between force and focal adhesion (FA) dynamics is unclear. Substrate stiffness and contractility regulate the relationship between force and vinculin, but not paxillin, turnover at FAs. Substrate stiffness and contractility also regulate whether vinculin and paxillin turnover dynamics are correlated at FAs.

Keywords: contractility; vinculin paxillin; force; substrate stiffness

Journal Title: Molecular Biology of the Cell
Year Published: 2017

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