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Systematic analysis of Ca2+ homeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles

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The global landscape of Ca2+ homeostasis in budding yeast is deciphered. Quantified morphological responses under high concentration of Ca2+ and obtained high-dimensional Ca2+-genetic interaction profiles show functional gene clusters, which… Click to show full abstract

The global landscape of Ca2+ homeostasis in budding yeast is deciphered. Quantified morphological responses under high concentration of Ca2+ and obtained high-dimensional Ca2+-genetic interaction profiles show functional gene clusters, which are used to build a global network among the Ca2+ homeostasis units acting in various cellular compartments.

Keywords: homeostasis; ca2 homeostasis; interaction profiles; genetic interaction

Journal Title: Molecular Biology of the Cell
Year Published: 2017

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