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The diversion of the β-secretase BACE1 from the endo-lysosomal pathway to recycling endosomes is important in the regulation of amyloid beta production. Here we define BACE1 transport from early to… Click to show full abstract
The diversion of the β-secretase BACE1 from the endo-lysosomal pathway to recycling endosomes is important in the regulation of amyloid beta production. Here we define BACE1 transport from early to recycling endosomes and identify essential roles for the SNX4-mediated, signal-independent pathway and for a signal-mediated, GGA1-dependent pathway.
Keywords:
recycling endosomes;
production;
signal dependent;
gga1 regulates;
regulates signal;
bace1
Journal Title: Molecular Biology of the Cell
Year Published: 2018
Link to full text (if available)
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Journal Title: Molecular Biology of the Cell
Year Published: 2018
Link to full text (if available)
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recommendations!