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Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin

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By binding and directing the cycling Golgi protein GPP130 to lysosomes, the sorting receptor sortilin mediates the manganese-induced GPP130 down-regulation that protects against Shiga toxicosis. Click to show full abstract

By binding and directing the cycling Golgi protein GPP130 to lysosomes, the sorting receptor sortilin mediates the manganese-induced GPP130 down-regulation that protects against Shiga toxicosis.

Keywords: turnover gpp130; gpp130; induced trafficking; manganese induced; gpp130 mediated; trafficking turnover

Journal Title: Molecular Biology of the Cell
Year Published: 2017

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