LAUSR

technologists tasked with running the assay. The benefits and value of building a custom LIMS is no doubt appealing, but the challenges and risks faced while accomplishing that goal proved to be a difficult endeavor. Our clinical genomics laboratory was granted the opportunity to construct a custom LIMS to be utilized for whole exome sequencing workflows. With careful consideration of the cost and time required to develop a custom software tool that needs to mimic our current procedures, our team quickly set forth to develop a project plan. Unlike many “out of the box” systems, our development would require specific insight and technical configurations. Our team arranged workshops with both laboratory technicians and software developers to gather user requirements. We vigilantly managed time as to not disrupt ongoing clinical work. Ultimately, despite setbacks and pivots, we accomplished our mission. Due to intense project planning, multi-team communication, a clear vision, and, most importantly, user input, we created and implemented a robust automated LIMS without disrupting our clinical workflow. At the conclusion of this project, much was learned. It is critical to avoid “scope-creep” (the tendency for project goals to grow beyond the original vision). For the sake of time, implement a minimal viable product, test it, release it, and then iterate on later versions. Budget for both cost and personnel bandwidth. Understand risks, and be resourceful enough to adapt to changing goals.