LAUSR

To examine the frequency of early vascular aging and risk factors in an adult population with age ≤50 years old in Kailuan. A total of 21,952 subjects aged ≤50 years without previous history of cardiovascular and cerebrovascular diseases and having completed brachial-ankle pulse wave velocity test in 2010–2016 were recruited. The mean plus 2 standard deviations (mean + 2SD) of brachial-ankle pulse wave velocity in 1,813 healthy population without hypertension, diabetes, dyslipidemia, and smoking were calculated and used as the reference value for early vascular aging. The stepwise regression multivariate logistic regression model was used to analyze the influencing factors for early vascular aging in different age and gender groups. The average detection rate of early vascular aging in this population was 15.0% with 12.9% in 30 years or less, 14.8% between 30 and 40 years, and 15.6% between 40 and 50 years. Furthermore, age, male, resting heart rate, high sensitivity C-reactive protein, smoking, hypertension, and diabetes were risk factors for early vascular aging with odds ratio values (95% confidence interval) of 1.02 (1.01–1.03), 2.51 (2.10–3.00), 1.04 (1.03–1.04), 1.09 (1.05–1.13), 1.11 (1.04–1.20), 1.05 (1.00–1.11), 3.55 (3.13–4.03), and 1.69 (1.38–2.08), respectively. The risk factors for early vascular aging in women with gestational hypertension were 4.27 times higher than those in women without (95% confidence interval 1.34–13.53). The frequency of early vascular aging is 15.0% in adult population ≤50 years old. Risk factors for early vascular aging include age, male, resting heart rate, high sensitivity C-reactive protein, smoking, hypertension, diabetes, and in women, the pregnancy-induced hypertension.