LAUSR

BACKGROUND Urine biomarkers of kidney tubule health may distinguish aspects of kidney damage that cannot be captured by current glomerular measures. Associations of clinical risk factors with specific kidney tubule biomarkers have not been evaluated in detail. METHODS We performed a cross-sectional study in the Systolic Blood Pressure Intervention Trial among 2436 participants with baseline estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m 2. Associations between demographic and clinical characteristics with urine biomarkers of kidney tubule health were evaluated using simultaneous multivariable linear regression of selected variables. RESULTS Each standard deviation higher age (9 years) was associated with 13% higher levels of chinase-3-like protein-1 (YKL-40), indicating higher levels of tubulointerstitial inflammation and repair. Men had 31% higher levels of alpha-1 microglobulin and 16% higher levels of beta-2 microglobulin, reflecting worse tubule resorptive function. Black race was associated with significantly higher levels of neutrophil gelatinase-associated lipocalin (12%) and lower kidney injury molecule-1 (26%) and uromodulin (22%). Each SD higher SBP (16 mmHg) was associated with 10% higher beta-2 microglobulin and 10% higher alpha-1 microglobulin, reflecting lower tubule resorptive function. CONCLUSIONS Clinical and demographic characteristics, such as race, sex and elevated systolic blood pressure, are associated with unique profiles of tubular damage which could reflect under-recognized patterns of kidney tubule disease among persons with decreased eGFR.