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plasma protein-A (PAPP-A) is a metalloproteinase that cleaves insulin-like growth factor 1 (IGF-1) from a circulating complex formed with insulin-like growth factor binding protein 4 (IGFBP4). Increased bioavailability of IGF1… Click to show full abstract
plasma protein-A (PAPP-A) is a metalloproteinase that cleaves insulin-like growth factor 1 (IGF-1) from a circulating complex formed with insulin-like growth factor binding protein 4 (IGFBP4). Increased bioavailability of IGF1 subsequently impacts on tumour biology. PAPP-A is produced in increasing levels until term by the syncytiotrophoblast cells in the human placenta. High levels of PAPP-A have been associated with progression in other tumour types.
Keywords:
active metabolite;
dried plasma;
sunitinib active;
plasma spot;
spot assay;
assay sunitinib
Journal Title: Annals of Oncology
Year Published: 2017
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Journal Title: Annals of Oncology
Year Published: 2017
Link to full text (if available)
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recommendations!