LAUSR

Abstract Background Impaired renal function in multiple myeloma (MM) patients is common and will generally improve after treatment. However, some patients showed no improvement after therapy, thus, other causes of renal impairment must be suspected. Case Illustration This is a case about a 57-year-old male MM patient with co-existing chronic renal failure due to chronic pyelonephritis and hypertension. Patients underwent routine hemodialysis twice a week and received intravenous bortezomib 1.3 mg/m2 a day after hemodialysis, melphalan 9 mg/m2 and oral prednisone 60 mg/m2 day -1 to -4. However, there was no significant improvement in renal function. After undergoing three cycles of chemotherapy, patients experienced worsening due to sepsis, deteriorating renal function and death. Conclusion It is a challenge to make early diagnosis and choose appropriate treatment in multiple myeloma patients with co-existing chronic renal failure. Management of MM with chronic renal failure includes supportive therapies and treatment of myeloma using the latest generation of drugs.