LAUSR

BACKGROUND Exosomes are regenerative mediators for skin rejuvenation. In the context of aesthetic medicine, platelets are an ideal source for exosomal isolation given their role in skin healing. Human platelet extract (HPE) is an allogeneic exosome product derived from US-sourced, leukocyte-reduced apheresed platelets with consistent purity and potency. OBJECTIVES To better characterize the saftey and tolerability of novel human platelet extract (plated) Intensive Repair Serum, (Rion Aesthetics, Rochester, MN) and its maximal effects on skin rejuvenation at 6 weeks. METHODS This prospective, single-arm, non-randomized, longitudinal study investigated the safety and efficacy of human platelet extract. Structured sub-analysis evaluated multifactorial improvement in skin health following standardized skin care regimen to determine the maximal effect. Evaluation at baseline and 6-weeks included subject questionnaires and photodocumentation using VISIA-CR Generation 5 3D PRIMOS (Canfield Scientific Inc, Fairfield, NJ). RESULTS VISIA-CR imaging yielded quantifiable and statistically significant improvements in overall skin health (named "Skin Health Score" [SHS]), calculated by multiplying the luminosity and color evenness scores and dividing the result by wrinkle area x brown spot area x redness area). A greater score correlated to greater overall skin health and there was a statistically significant mean delta improvement 224.2 ± 112.8 (mean ± SD, p ≤ 0.0001) in SHS at 6-weeks compared to baseline. This correlated to reduction in redness, wrinkles, and melanin production across all cosmetic units (p = 0.005, p=0.0023, p ≤ 0.0001, respectively) and significant improvements in luminosity and color evenness (p ≤ 0.001). CONCLUSIONS A topically applied platelet-derived exosome product, human platelet extract, induced normalization to skin health at 4-6 weeks with improved various clinical measures of facial photodamage and cutaneous aging. It is safe, well-tolerated, and well-liked by subjects.