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BACKGROUND Circumferential liposuction may cause a dilution anemia due to a high volume of infiltrated tumescent. Studies analyzing the percentage of absorbed tumescent as well as the safe limit of tumescent infiltration are currently lacking. OBJECTIVES The objective was to calculate the average volume uptake of administered fluids in power-assisted liposuction. Furthermore, we sought to calculate a practical formula to determine the amount of fluid that can safely be administered without inducing symptomatic dilution anemia or hypervolemia. METHODS Patients undergoing circumferential liposuction with power-assisted tumescent infiltration were included in a prospective clinical study. All relevant administered and excreted volumes during and after the operation were collected. Preoperative versus postoperative hemogram results were compared and the hemodynamic parameters were followed for 24 hours. The average volume uptake was calculated based on the measured volumes, as well as the ratio between administered volumes and the patient's blood volume. RESULTS 30 patients were included during September 2021. The average volume uptake was 58% for a calculated 1.11 to 1 infiltration to aspiration ratio. There was a mean drop of 1.9 g/dl and 4.6% for the postoperative Hb and Hct, respectively, with a stable Red Blood Cell level. All patients remained hemodynamically stable without the need for blood transfusion or prolonged oxygen need. The average tumescent versus blood volume ratio was 85.0%. CONCLUSIONS In circumferential liposuction with power-assisted infiltration, the infiltrated tumescent volume should remain below 85% of the patient's blood volume to minimize the risk of a symptomatic dilution anemia or hypervolemia.