MOTIVATION We report on a new single-cell DNA sequence simulator, SimSCSnTree, which generates an evolutionary tree of cells and evolves single nucleotide variants (SNVs) and copy number aberrations (CNAs) along… Click to show full abstract
MOTIVATION We report on a new single-cell DNA sequence simulator, SimSCSnTree, which generates an evolutionary tree of cells and evolves single nucleotide variants (SNVs) and copy number aberrations (CNAs) along its branches. Data generated by the simulator can be used to benchmark tools for single-cell genomic analyses, particularly in cancer where SNVs and CNAs are ubiquitous. AVAILABILITY AND IMPLEMENTATION SimSCSnTree is now on BioConda and also is freely available for download at https://github.com/compbiofan/SimSCSnTree.git with detailed documentation.
Journal Title: Bioinformatics
Year Published: 2022
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