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Mirage 2.0: fast and memory-efficient reconstruction of gene-content evolution considering heterogeneous evolutionary patterns among gene families

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Abstract Summary We present Mirage 2.0, which accurately estimates gene-content evolutionary history by considering heterogeneous evolutionary patterns among gene families. Notably, we introduce a deterministic pattern mixture model, which makes… Click to show full abstract

Abstract Summary We present Mirage 2.0, which accurately estimates gene-content evolutionary history by considering heterogeneous evolutionary patterns among gene families. Notably, we introduce a deterministic pattern mixture model, which makes Mirage substantially faster and more memory-efficient to be applicable to large datasets with thousands of genomes. Availability and implementation The source code is freely available at https://github.com/fukunagatsu/Mirage. Supplementary information Supplementary data are available at Bioinformatics online.

Keywords: considering heterogeneous; evolutionary patterns; gene content; patterns among; gene; heterogeneous evolutionary

Journal Title: Bioinformatics
Year Published: 2022

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