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Hyperglycemia-induced TET3 insufficiency is responsible for maternal transmission of glucose intolerance

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Hyperglycemia-induced TET3 insufficiency is responsible for maternal transmission of glucose intolerance† Wei Yan1,2,* and Marisa S. Bartolomei3,* 1The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA… Click to show full abstract

Hyperglycemia-induced TET3 insufficiency is responsible for maternal transmission of glucose intolerance† Wei Yan1,2,* and Marisa S. Bartolomei3,* 1The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA 2Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA 3Department of Cell and Developmental Biology, Perelman School of Medicine, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA *Correspondence: Wei Yan, The Lundquist Institute at Harbor-UCLA, 1124 West Carson Street, Torrance, CA 90502. Tel: 775-338-985; E-mail: [email protected]; Marisa S. Bartolomei, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd., Philadelphia, PA 19104. Tel: 215-898-9063; [email protected] †Grant Support: W.Y. is supported by grants from the NIH (HD071736, HD085506, HD098593, HD0085506, HD099924, and P30GM110767) and the Templeton Foundation (PID: 61174). M.S.B. is supported by grants from the NIH (HD068157, GM051279, and HD092266).

Keywords: hyperglycemia induced; insufficiency responsible; tet3 insufficiency; induced tet3; medicine; biology

Journal Title: Biology of Reproduction
Year Published: 2022

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