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Parkin/PINK1 deficiency impairs mitophagy in mice, leading to the release of mitochondrial DNA (mtDNA) and triggering inflammation. Borsche et al. now demonstrate elevated serum Interleukin 6 and circulating cell-free mtDNA… Click to show full abstract
Parkin/PINK1 deficiency impairs mitophagy in mice, leading to the release of mitochondrial DNA (mtDNA) and triggering inflammation. Borsche et al. now demonstrate elevated serum Interleukin 6 and circulating cell-free mtDNA also in patients with Parkin/PINK1 mutations, further implicating inflammation in Parkinson’s disease.
Keywords:
mitochondrial damage;
inflammation highlights;
highlights biomarkers;
inflammation;
associated inflammation;
damage associated
Journal Title: Brain
Year Published: 2020
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Journal Title: Brain
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!