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Effects of dopamine on reinforcement learning in Parkinson’s disease depend on motor phenotype

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See Manohar (doi:10.1093/brain/awaa363) for a scientific commentary on this article. Parkinson’s disease is complicated by great variability in symptoms. Van Nuland et al. report that the well-established effects of levodopa… Click to show full abstract

See Manohar (doi:10.1093/brain/awaa363) for a scientific commentary on this article. Parkinson’s disease is complicated by great variability in symptoms. Van Nuland et al. report that the well-established effects of levodopa on reinforcement learning apply only to patients without tremor symptoms, suggesting a need to revisit neurocognitive models of dopaminergic function in Parkinson’s disease.

Keywords: disease; dopamine reinforcement; reinforcement learning; effects dopamine; parkinson disease

Journal Title: Brain
Year Published: 2020

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