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18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy

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The extent to which the tau tracer [18F]AV-1451 can differentiate between tauopathies is unknown. By comparing patients with Alzheimer’s disease and progressive supranuclear palsy (PSP), Passamonti et al. show that… Click to show full abstract

The extent to which the tau tracer [18F]AV-1451 can differentiate between tauopathies is unknown. By comparing patients with Alzheimer’s disease and progressive supranuclear palsy (PSP), Passamonti et al. show that [18F]AV-1451 displays greater specificity for Alzheimer-related tau pathology than PSP-related pathology. A machine learning algorithm correctly diagnosed 94% of cases.

Keywords: supranuclear palsy; alzheimer disease; pathology; 18f 1451; disease progressive; progressive supranuclear

Journal Title: Brain
Year Published: 2017

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