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Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy

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Prion-like, trans-neuronal spread of tau pathology in humans is controversial. By evaluating tau burden and functional connectivity in living patients, Cope et al. demonstrate relationships consistent with this in Alzheimer's… Click to show full abstract

Prion-like, trans-neuronal spread of tau pathology in humans is controversial. By evaluating tau burden and functional connectivity in living patients, Cope et al. demonstrate relationships consistent with this in Alzheimer's disease but not progressive supranuclear palsy. Tau distribution in the latter is better explained by metabolic demand and trophic support.

Keywords: tau; alzheimer disease; burden functional; tau burden; disease progressive; progressive supranuclear

Journal Title: Brain
Year Published: 2018

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