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Distinct HLA associations of LGI1 and CASPR2-antibody diseases

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The mechanisms responsible for the generation of LGI1- or CASPR2-antibodies are unknown. Binks et al. describe two strikingly dichotomous HLA-associations, most significantly in HLA-DRB1*07:01 for LGI1, and HLA-DRB1*11:01 for CASPR2.… Click to show full abstract

The mechanisms responsible for the generation of LGI1- or CASPR2-antibodies are unknown. Binks et al. describe two strikingly dichotomous HLA-associations, most significantly in HLA-DRB1*07:01 for LGI1, and HLA-DRB1*11:01 for CASPR2. Prediction of antigen-specific HLA-binding peptides generates testable hypotheses for T cell identification.

Keywords: distinct hla; lgi1 caspr2; associations lgi1; hla; caspr2; hla associations

Journal Title: Brain
Year Published: 2018

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