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Physiological mechanisms of thalamic ventral intermediate nucleus stimulation for tremor suppression

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Ventral intermediate thalamic stimulation is effective in treating essential tremor and tremor-dominant Parkinson’s disease, but its precise mechanism of action is unclear. Milosevic et al. show that thalamic inhibition of… Click to show full abstract

Ventral intermediate thalamic stimulation is effective in treating essential tremor and tremor-dominant Parkinson’s disease, but its precise mechanism of action is unclear. Milosevic et al. show that thalamic inhibition of neuronal firing is necessary for tremor reduction, suggesting that the thalamus acts as a filter for uncoupling central and peripheral tremor networks.

Keywords: ventral intermediate; mechanisms thalamic; stimulation; physiological mechanisms; thalamic ventral; tremor

Journal Title: Brain
Year Published: 2018

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