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Glyceryl trinitrate administration causes prolonged mechanical allodynia in rodents, which correlates temporally with delayed migraine attacks in patients. Marone et al. show that the allodynia is mediated by TRPA1 activation… Click to show full abstract
Glyceryl trinitrate administration causes prolonged mechanical allodynia in rodents, which correlates temporally with delayed migraine attacks in patients. Marone et al. show that the allodynia is mediated by TRPA1 activation in cell bodies of trigeminal neurons and ensuing oxidative stress. This neuronal pathway may be of relevance to migraine-like headaches.
Keywords:
glyceryl trinitrate;
trpa1 nox;
nox soma;
soma trigeminal;
glyceryl
Journal Title: Brain
Year Published: 2018
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Journal Title: Brain
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!