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Frigerio et al. report that pro-resolving mechanisms of neuroinflammation are dysregulated during epileptogenesis, thereby promoting a persistent neuroinflammatory response that contributes to seizure generation and cognitive deficits. Boosting endogenous resolution… Click to show full abstract
Frigerio et al. report that pro-resolving mechanisms of neuroinflammation are dysregulated during epileptogenesis, thereby promoting a persistent neuroinflammatory response that contributes to seizure generation and cognitive deficits. Boosting endogenous resolution responses by administering a specific lipid mediator improves disease outcomes in a murine epilepsy model, suggesting a novel treatment avenue.
Keywords:
acid derived;
neuroinflammation;
docosapentaenoic acid;
protectin promotes;
derived protectin;
promotes resolution
Journal Title: Brain
Year Published: 2018
Link to full text (if available)
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Journal Title: Brain
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!