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See Bechek and Gitler (doi:10.1093/brain/awy294) for a scientific commentary on this article. Mutations in the endosome-associated protein CHMP2B cause frontotemporal dementia (FTD). Clayton et al. report a mechanism for CHMP2B-mediated… Click to show full abstract
See Bechek and Gitler (doi:10.1093/brain/awy294) for a scientific commentary on this article. Mutations in the endosome-associated protein CHMP2B cause frontotemporal dementia (FTD). Clayton et al. report a mechanism for CHMP2B-mediated neuronal dysfunction and a potential therapeutic strategy targeting the TMEM106B gene, a major risk factor for FTD. Targeting TMEM106B may be relevant to a broad range of FTDs.
Keywords:
frontotemporal dementia;
chmp2b;
causative chmp2b;
dementia causative;
tmem106b
Journal Title: Brain
Year Published: 2018
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Journal Title: Brain
Year Published: 2018
Link to full text (if available)
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recommendations!